C-Reactive protein concentrations in reproductive-aged women with major mood disorders

Elizabeth Torres*, Katelynn B. Zumpf, Jody D. Ciolino, Crystal T. Clark, Dorothy K. Sit, Emily S. Miller, Katherine L. Wisner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


To examine associations between high sensitivity C-reactive protein (CRP) concentrations and depressive symptoms in reproductive-aged women with mood disorders. Women (N = 86) with major depressive or bipolar disorder in a specialized mood disorders program provided plasma samples which were analyzed for CRP concentrations and categorized by tertiles (T1, low; T2, middle; T3 high). Depressive symptoms were assessed with the Inventory of Depressive Symptoms. We hypothesized that CRP concentrations would be significantly associated with the following: (1) depressive symptoms; (2) pregnancy, (3) body mass index, and (4) counts of white blood cells and absolute neutrophils and percentage of segmented neutrophils. The distribution of CRP concentrations was highly skewed with a median of 2.45 mg/L and an interquartile range 0.90 − 8.17 mg/L. Elevated plasma levels of CRP were not associated with depressive symptoms, which did not differ by tertile group either before or after adjusting for BMI, pregnancy status, and their interactions. Women in T3 had 5 times greater odds of pregnancy compared to women in T1 (p =.021). However, women in T2 had 11% greater BMI on average (p = 0.023), and women in T3 had 47% greater BMI compared to those in T1 (p < 0.001). Women in T3 had higher mean white blood cell counts than those in T1 and T2, the percentage of neutrophils was higher in T2 and T3 compared to T1, and women in T3 had higher absolute neutrophil counts compared to T1. CRP concentrations varied widely and were significantly elevated in reproductive-aged women with high BMI and current pregnancy, but not with depressive symptoms in this sample of depressed women.

Original languageEnglish (US)
Pages (from-to)577-584
Number of pages8
JournalArchives of Women's Mental Health
Issue number3
StatePublished - Jun 2022


  • C-Reactive protein
  • Inflammatory depression
  • Pregnancy, women’s health

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health


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