C1-3 adrenergic medullary neurones project to the paraventricular thalamic nucleus in the rat

Adrenergic afferents to the thalamus are almost entirely concentrated in the paraventricular thalamic nucleus (PV). The origins of this projection from medullary C1-3 neurones were quantified, using a combination of retrograde fluorescent markers and immunocytochemical localisation for phenylethanolamine N-methyltransferase (PNMT) in the rat. C1 neurones contributed 51%, C2 29% and C3 20% of the total adrenergic input. Many apparently non-adrenergic retrogradely labelled neurones were also found amongst the C1-3 neurones. The C3 region contained the largest adrenergic population (67%) of retrogradely labelled neurones. The neuronal networks associated with PV suggest a role for these adrenergic projections in regulating specific autonomic, locomotor and behavioural events.