C1-3 adrenergic medullary neurones project to the paraventricular thalamic nucleus in the rat

O. T. Phillipson*, M. C. Bohn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Adrenergic afferents to the thalamus are almost entirely concentrated in the paraventricular thalamic nucleus (PV). The origins of this projection from medullary C1-3 neurones were quantified, using a combination of retrograde fluorescent markers and immunocytochemical localisation for phenylethanolamine N-methyltransferase (PNMT) in the rat. C1 neurones contributed 51%, C2 29% and C3 20% of the total adrenergic input. Many apparently non-adrenergic retrogradely labelled neurones were also found amongst the C1-3 neurones. The C3 region contained the largest adrenergic population (67%) of retrogradely labelled neurones. The neuronal networks associated with PV suggest a role for these adrenergic projections in regulating specific autonomic, locomotor and behavioural events.

Original languageEnglish (US)
Pages (from-to)67-70
Number of pages4
JournalNeuroscience Letters
Volume176
Issue number1
DOIs
StatePublished - Jul 18 1994

Keywords

  • Epinephrine
  • Medulla oblongata
  • Phenethanolamine N-methyltransferase
  • Thalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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