C4ST-1 and chondroitin sulfate in growth factor signaling, development, and cancer

Catherine M. Willis, Robert D. Prinz, Michael Klüppel*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The glycosaminoglycan chondroitin sulfate consists of unbranched chains of repeating disaccharides. CS chains are attached to core proteins to form CSproteoglycans, located on the cell surface and in the extracellular matrix. The biological roles of specific chondroitin sulfate forms, as well as enzymes involved in their biosynthesis, in development and disease have recently generated great interest. In this chapter we summarize current knowledge that suggests important biological roles for specific chondroitin sulfate forms, the balance of chondroitin sulfation, and chondroitin sulfotransferase enzymes. In particular, we will discuss recent findings regarding the functional roles of chondroitin-4-sulfotransferase-1 (C4ST-1) and its products in mouse and zebrafish development, signaling pathways and cancer. Future research will undoubtedly provide exciting and novel insights into the functional roles of C4ST-1 and specific chondroitin sulfate forms in development processes, cancer progression, and associated cell signaling events.

Original languageEnglish
Title of host publicationSignaling, Gene Regulation and Cancer
EditorsS.R. Singh, M.K.M. Mishra
Place of PublicationNew York
PublisherNova Science Publishers, Inc.
Number of pages20
ISBN (Print)9781619420885
StatePublished - 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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