CAAX-box protein, prenylation process and carcinogenesis

Juehua Gao, Jie Liao, Guang-Yu Yang*

*Corresponding author for this work

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

CAAX proteins are widely involved in global cellular functions such as proliferation, differentiation, and carcinogenesis. As an important modulator of biological activity, signal transduction via protein prenylation is a crucial step for most CAAX protein functions, particularly for anchoring these CAAX proteins to cellular membrane system. With a better understanding of the molecular mechanisms of signal transduction and intracellular messaging in this process, CAAX protein prenylation may be of particular importance for elucidating the biologic events in carcinogenesis and provide potential approaches of selectively blocking the downstream signal cascade that allows carcinogenesis. Here, we mainly focus on the prenylation process of the clinically important CAAX box proteins, and their potential as a biomarker or preventive/therapeutic target in carcinogenesis.

Original languageEnglish (US)
Pages (from-to)312-325
Number of pages14
JournalAmerican Journal of Translational Research
Volume1
Issue number3
StatePublished - Sep 18 2009

Keywords

  • Biomarkers
  • CAAX box proteins
  • Carcinogenesis
  • Prenylation
  • Signal transduction

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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