Calcification of Bruch's Membrane in Angioid Streaks With Homozygous Sickle Cell Disease

Lee M. Jampol; Richard O'grady; Graham Serjeant; Ralph C. Eagle

doi:10.1001/archopht.1987.01060010099039

Calcification of Bruch's Membrane in Angioid Streaks With Homozygous Sickle Cell Disease

Lee M. Jampol, Richard O'grady, Graham Serjeant, Ralph C. Eagle

Ophthalmology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Histochemical and light and electron microscopic studies of two eyes of a patient with homozygous sickle cell disease and angioid streaks demonstrated heavy calcification and breaks in Bruch's membrane. We were unable to demonstrate iron deposition by histochemical techniques or transmission electron microscopy. These studies suggest that calcification rather than iron deposition is the major factor leading to brittleness of Bruch's membrane in patients with hemolytic anemia and angioid streaks.

Original language	English (US)
Pages (from-to)	93-98
Number of pages	6
Journal	Archives of ophthalmology
Volume	105
Issue number	1
DOIs	https://doi.org/10.1001/archopht.1987.01060010099039
State	Published - Jan 1987

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1987.01060010099039

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abstract = "Histochemical and light and electron microscopic studies of two eyes of a patient with homozygous sickle cell disease and angioid streaks demonstrated heavy calcification and breaks in Bruch's membrane. We were unable to demonstrate iron deposition by histochemical techniques or transmission electron microscopy. These studies suggest that calcification rather than iron deposition is the major factor leading to brittleness of Bruch's membrane in patients with hemolytic anemia and angioid streaks.",

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AB - Histochemical and light and electron microscopic studies of two eyes of a patient with homozygous sickle cell disease and angioid streaks demonstrated heavy calcification and breaks in Bruch's membrane. We were unable to demonstrate iron deposition by histochemical techniques or transmission electron microscopy. These studies suggest that calcification rather than iron deposition is the major factor leading to brittleness of Bruch's membrane in patients with hemolytic anemia and angioid streaks.

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Calcification of Bruch's Membrane in Angioid Streaks With Homozygous Sickle Cell Disease

Abstract

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