Calcification of Bruch's Membrane in Angioid Streaks With Homozygous Sickle Cell Disease

Lee M. Jampol, Richard O'grady, Graham Serjeant, Ralph C. Eagle

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Histochemical and light and electron microscopic studies of two eyes of a patient with homozygous sickle cell disease and angioid streaks demonstrated heavy calcification and breaks in Bruch's membrane. We were unable to demonstrate iron deposition by histochemical techniques or transmission electron microscopy. These studies suggest that calcification rather than iron deposition is the major factor leading to brittleness of Bruch's membrane in patients with hemolytic anemia and angioid streaks.

Original languageEnglish (US)
Pages (from-to)93-98
Number of pages6
JournalArchives of ophthalmology
Volume105
Issue number1
DOIs
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Ophthalmology

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