Calcinosis Biomarkers in Adult and Juvenile Dermatomyositis

For the International Myositis Assessment, Clinical Studies Group (IMACS) Calcinosis Scientific Interest Group

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by muscle weakness and cutaneous manifestations in adults and children. Calcinosis, a complication of DM, is the abnormal deposition of insoluble calcium salts in tissues, including skin, subcutaneous tissue, tendons, fascia, and muscle. Calcinosis is more commonly seen in juvenile DM (JDM), but also develops in adult DM. Although the mechanism of calcinosis remains unclear, several pathogenic hypotheses have been proposed, including intracellular accumulation of calcium secondary to an alteration of the cellular membrane by trauma and inflammation, local vascular ischemia, dysregulation of mechanisms controlling the deposition and solubility of calcium and phosphate, and mitochondrial damage of muscle cells. Identifying calcinosis biomarkers is important for early disease detection and risk assessment, and may lead to novel therapeutic targets for the prevention and treatment of DM-associated calcinosis. In this review, we summarize myositis autoantibodies associated with calcinosis in DM, histopathology and chemical composition of calcinosis, genetic and inflammatory markers that have been studied in adult DM and JDM-associated calcinosis, as well as potential novel biomarkers.

Original languageEnglish (US)
Article number102533
JournalAutoimmunity Reviews
Volume19
Issue number6
DOIs
StatePublished - Jun 2020
Externally publishedYes

Keywords

  • Autoantibodies
  • Calcinosis
  • Dermatoyositis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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