Calcinosis in scleroderma made crystal clear

Vivien Hsu*, John Varga, Naomi Schlesinger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Purpose of reviewReview the current state of knowledge and recent developments in the field of scleroderma-related calcinosis [systemic sclerosis (SSc)-calcinosis], focusing on emerging information related to pathophysiology.Recent findingsRecent studies have begun to characterize that factors that regulate ectopic mineralization, and those that underlie the imbalance of promoters and inhibitors of this process in SSc.SummaryCalcinosis cutis due to ectopic mineralization is a common and highly troublesome complication of SSc. Despite its significant prevalence and clinical impact, the pathogenesis is poorly understood and effective treatment is lacking. More research to better understand the pathophysiology is needed for the identification of novel management strategies for this severe complication of SSc.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalCurrent opinion in rheumatology
Issue number6
StatePublished - Nov 1 2019


  • calcinosis
  • crystals
  • systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology


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