Calcium, Bioenergetics, and Parkinson's Disease

Enrico Zampese; D. James Surmeier

doi:10.3390/cells9092045

Calcium, Bioenergetics, and Parkinson's Disease

Enrico Zampese, D. James Surmeier

Neuroscience

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca2+ oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca2+ oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.

Original language	English (US)
Article number	2048
Journal	Cells
Volume	9
Issue number	9
DOIs	https://doi.org/10.3390/cells9092045
State	Published - Sep 8 2020

Keywords

Ca2+
Parkinson’s disease
bioenergetics
dopaminergic neurons
mitochondria
neurodegeneration
oxidative stress
substantia nigra

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells9092045

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abstract = "Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca2+ oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca2+ oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.",

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AB - Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca2+ oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca2+ oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.

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KW - dopaminergic neurons

KW - mitochondria

KW - neurodegeneration

KW - oxidative stress

KW - substantia nigra

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Calcium, Bioenergetics, and Parkinson's Disease

Abstract

Keywords

ASJC Scopus subject areas

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