Calcium, Bioenergetics, and Parkinson's Disease

Enrico Zampese, D. James Surmeier

Research output: Contribution to journalReview articlepeer-review


Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca2+ oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca2+ oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.

Original languageEnglish (US)
Issue number9
StatePublished - Sep 8 2020


  • Ca2+
  • Parkinson’s disease
  • bioenergetics
  • dopaminergic neurons
  • mitochondria
  • neurodegeneration
  • oxidative stress
  • substantia nigra

ASJC Scopus subject areas

  • Medicine(all)

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