Calcium, Bioenergetics, and Parkinson's Disease

Enrico Zampese, D. James Surmeier

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Degeneration of substantia nigra (SN) dopaminergic (DAergic) neurons is responsible for the core motor deficits of Parkinson's disease (PD). These neurons are autonomous pacemakers that have large cytosolic Ca2+ oscillations that have been linked to basal mitochondrial oxidant stress and turnover. This review explores the origin of Ca2+ oscillations and their role in the control of mitochondrial respiration, bioenergetics, and mitochondrial oxidant stress.

Original languageEnglish (US)
Issue number9
StatePublished - Sep 8 2020


  • Ca2+
  • Parkinson’s disease
  • bioenergetics
  • dopaminergic neurons
  • mitochondria
  • neurodegeneration
  • oxidative stress
  • substantia nigra

ASJC Scopus subject areas

  • Medicine(all)


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