Calcium-Channel Blockers in Primary Pulmonary Hypertension

Daniel J. Gottlieb, Stuart Rich, Elizabeth Kaufmann, Paul S. Levy

Research output: Contribution to journalLetterpeer-review


To the Editor: In the July 9 issue, Rich et al.* present strong evidence that patients with primary pulmonary hypertension whose pulmonary vascular resistance and pulmonary-artery pressure respond to treatment with calcium-channel blockers have markedly improved survival, as compared with both historical controls who were not selected on the basis of their responsiveness to calcium-channel blockers and patients who are not responsive to calcium-channel blockers. Unfortunately, it remains unclear whether this improved survival is a result of pharmacotherapy or whether a responsive pulmonary vasculature is prognostically favorable, independent of therapy. The authors have addressed this concern by demonstrating that survival…

Original languageEnglish (US)
Pages (from-to)1458-1459
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - Nov 12 1992

ASJC Scopus subject areas

  • Medicine(all)


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