Calcium channels in undifferentiated PC12 rat pheochromocytoma cells

Damir Janigro, Gianmaria Maccaferri, Jacopo Meldolesi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Undifferentiated rat pheochromocytoma PC12 cells were voltage clamped using the whole cell technique. After blockade of outward currents, calcium currents were elicited from -40 and -100 mV. A subpopulation of cells displayed only one current component activated at -10 mV and slowly decaying. In other cells this current coexisted with a component activated around -40 mV and decaying with a faster time constant. We conclude that undifferentiated PC12 cells can express two types of calcium channels, L (long-lasting) and N (neuronal)-type channels.

Original languageEnglish (US)
Pages (from-to)398-400
Number of pages3
JournalFEBS Letters
Volume255
Issue number2
DOIs
StatePublished - Sep 25 1989

Keywords

  • (PC12)
  • Calcium channel
  • Neural growth factor
  • Patch clamp

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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