@article{6faac27978504b18af31d27fa6df0edb,
title = "Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging",
abstract = "Misregulation of extracellular Ca2+ can indicate bone-related pathologies. New, noninvasive tools are required to image Ca2+ fluxes and fluorine magnetic resonance imaging (19F-MRI) is uniquely suited to this challenge. Here, we present three, highly fluorinated peptide amphiphiles that self-assemble into nanoribbons in buffered saline and demonstrate these nanostructures can be programmed to change 19F-NMR signal intensity as a function of Ca2+ concentration. We determined these nanostructures show significant reduction in 19F-NMR signal as nanoribbon width increases in response to Ca2+, corresponding to 19F-MR image intensity reduction. Thus, these peptide amphiphiles can be used to quantitatively image biologically relevant Ca2+ concentrations.",
keywords = "F, MRI, calcium sensing, morphology, peptide amphiphile",
author = "Preslar, {Adam T.} and Lilley, {Laura M.} and Kohei Sato and Shanrong Zhang and Chia, {Zer Keen} and Stupp, {Samuel I.} and Meade, {Thomas J.}",
note = "Funding Information: We gratefully acknowledge funding from NIH NHLBI: P01HL10879, NIH NICDR: 5R01DE015920, and NIH NIBIB: R01EB005866. This research was also supported by a Catalyst Award from the Louis A. Simpson and Kimberly K. Querrey Center for Regenerative Nanomedicine at Northwestern University. Compound purification and characterization was performed at Northwestern{\textquoteright}s SQI Peptide Synthesis Core, Integrated Molecular Structure Education and Research Center (IMSERC), Bioimaging Facility (BIF) and Keck Biophysics Facility. The U.S. Army Research Office, the U.S. Army Medical Research and Materiel Command, and Northwestern University provided funding to develop the Peptide Synthesis facility and ongoing support is being received from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205). We also thank Prof. Liam Palmer helpful discussions and Mark Seniw for graphics. F-MRI was conducted at the Advanced Imaging Research Center, UT-Southwestern. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = nov,
day = "22",
doi = "10.1021/acsami.7b07828",
language = "English (US)",
volume = "9",
pages = "39890--39894",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "46",
}