Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging

Adam T. Preslar, Laura M. Lilley, Kohei Sato, Shanrong Zhang, Zer Keen Chia, Samuel I. Stupp*, Thomas J. Meade

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Misregulation of extracellular Ca2+ can indicate bone-related pathologies. New, noninvasive tools are required to image Ca2+ fluxes and fluorine magnetic resonance imaging (19F-MRI) is uniquely suited to this challenge. Here, we present three, highly fluorinated peptide amphiphiles that self-assemble into nanoribbons in buffered saline and demonstrate these nanostructures can be programmed to change 19F-NMR signal intensity as a function of Ca2+ concentration. We determined these nanostructures show significant reduction in 19F-NMR signal as nanoribbon width increases in response to Ca2+, corresponding to 19F-MR image intensity reduction. Thus, these peptide amphiphiles can be used to quantitatively image biologically relevant Ca2+ concentrations.

Original languageEnglish (US)
Pages (from-to)39890-39894
Number of pages5
JournalACS Applied Materials and Interfaces
Volume9
Issue number46
DOIs
StatePublished - Nov 22 2017

Keywords

  • F
  • MRI
  • calcium sensing
  • morphology
  • peptide amphiphile

ASJC Scopus subject areas

  • Materials Science(all)

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