TY - JOUR
T1 - Calcium intake and survival after colorectal cancer diagnosis
AU - Yang, Wanshui
AU - Ma, Yanan
AU - Smith-Warner, Stephanie
AU - Song, Mingyang
AU - Wu, Kana
AU - Wang, Molin
AU - Chan, Andrew T.
AU - Ogino, Shuji
AU - Fuchs, Charles S.
AU - Poylin, Vitaliy
AU - Ng, Kimmie
AU - Meyerhardt, Jeffrey A.
AU - Giovannucci, Edward L.
AU - Zhang, Xuehong
N1 - Funding Information:
C.S. Fuchs is a consultant/advisory board member for Entrinsic Health, Taiho, Genentech, CytomX, Eli Lilly, Sanofi, Unum Therapeutics, and Merck. K. Ng reports receiving commercial research grants from Pharmavite, LLC. No potential conflicts of interest were disclosed by the other authors.
Publisher Copyright:
© 2018 American Association for Cancer Research.
PY - 2019
Y1 - 2019
N2 - Purpose: Although evidence suggests an inverse association between calcium intake and colorectal cancer incidence, the influence of calcium on survival after colorectal cancer diagnosis remains unclear. Experimental Design: We prospectively assessed the association of postdiagnostic calcium intake with colorectal cancer–specific and overall mortality among 1,660 nonmetastatic colorectal cancer patients within the Nurses' Health Study and the Health Professionals Follow-up Study. Patients completed a validated food frequency questionnaire between 6 months and 4 years after diagnosis and were followed up for death. Multivariable hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated using Cox proportional hazards regression. Results: Comparing the highest with the lowest quartile intake of postdiagnostic total calcium, the multivariable HRs were 0.56 (95% CI, 0.32–0.96; P trend ¼ 0.04) for colorectal cancer–specific mortality and 0.80 (95% CI, 0.59–1.09; P trend ¼ 0.11) for all-cause mortality. Postdiagnostic supplemental calcium intake was also inversely associated with colorectal cancer–specific mortality (HR, 0.67; 95% CI, 0.42–1.06; P trend ¼ 0.047) and all-cause mortality (HR, 0.71; 95% CI, 0.54–0.94; P trend ¼ 0.008), although these inverse associations were primarily observed in women. In addition, calcium from diet or dairy sources was associated with lower risk in men. Conclusions: Higher calcium intake after the diagnosis may be associated with a lower risk of death among patients with colorectal cancer. If confirmed, these findings may provide support for the nutritional recommendations of maintaining sufficient calcium intake among colorectal cancer survivors.
AB - Purpose: Although evidence suggests an inverse association between calcium intake and colorectal cancer incidence, the influence of calcium on survival after colorectal cancer diagnosis remains unclear. Experimental Design: We prospectively assessed the association of postdiagnostic calcium intake with colorectal cancer–specific and overall mortality among 1,660 nonmetastatic colorectal cancer patients within the Nurses' Health Study and the Health Professionals Follow-up Study. Patients completed a validated food frequency questionnaire between 6 months and 4 years after diagnosis and were followed up for death. Multivariable hazard ratios (HRs) and 95% confidence intervals (95% CI) were calculated using Cox proportional hazards regression. Results: Comparing the highest with the lowest quartile intake of postdiagnostic total calcium, the multivariable HRs were 0.56 (95% CI, 0.32–0.96; P trend ¼ 0.04) for colorectal cancer–specific mortality and 0.80 (95% CI, 0.59–1.09; P trend ¼ 0.11) for all-cause mortality. Postdiagnostic supplemental calcium intake was also inversely associated with colorectal cancer–specific mortality (HR, 0.67; 95% CI, 0.42–1.06; P trend ¼ 0.047) and all-cause mortality (HR, 0.71; 95% CI, 0.54–0.94; P trend ¼ 0.008), although these inverse associations were primarily observed in women. In addition, calcium from diet or dairy sources was associated with lower risk in men. Conclusions: Higher calcium intake after the diagnosis may be associated with a lower risk of death among patients with colorectal cancer. If confirmed, these findings may provide support for the nutritional recommendations of maintaining sufficient calcium intake among colorectal cancer survivors.
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U2 - 10.1158/1078-0432.CCR-18-2965
DO - 10.1158/1078-0432.CCR-18-2965
M3 - Article
C2 - 30545821
AN - SCOPUS:85062950922
VL - 25
SP - 1980
EP - 1988
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 6
ER -