Calcium oscillation associated with reduced protein kinase C activities in ras-transformed NIH3T3 cells

Tao Fu, Yoshikazu Sugimoto, Tohru Oki, Shigeko Murakami, Yukio Okano, Yoshinori Nozawa*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We show here novel intracellular Ca2+ oscillation in ν-K-ras-transformed NIH3T3 cells induced by mitogenic peptide hormones, bradykinin and bombesin, as well as fetal calf serum. Induction of the Ca2+ oscillation is strongly correlated with the malignant properties and inversely with PKC activities in vitro and in vivo. These results suggest that the mitogen-induced Ca2+ oscillation is negatively regulated by PKC, which modulates Ca2+ influx in ν-K-ras-transformed NIH3T3 cells.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalFEBS Letters
Volume281
Issue number1-2
DOIs
StatePublished - Apr 9 1991

Keywords

  • Ca oscillation
  • Protein kinase C
  • ras-Transformed fibroblast

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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