Abstract
β2-Adrenergic agonists have been shown to regulate Na,K-ATPase in the alveolar epithelium by recruiting Na,K-ATPase-containing vesicles to the plasma membrane of alveolar epithelial cells (AEC). Here, we provide evidence that β2-agonists induce store-operated calcium entry (SOCE) in AECs. This calcium entry is necessary for β2-agonist-induced recruitment of Na,K-ATPase to the plasma membrane of AECs. Specifically, we show that β2-agonists induce SOCE via stromal interaction molecule 1 (STIM1)-associated calcium release-activated calcium (CRAC) channels. We also demonstrate that the magnitude of SOCE affects the abundance of Na,K-ATPase at the plasma membrane of AECs.
Original language | English (US) |
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Pages (from-to) | 4686-4693 |
Number of pages | 8 |
Journal | FEBS Letters |
Volume | 588 |
Issue number | 24 |
DOIs | |
State | Published - Dec 20 2014 |
Keywords
- Calcium channel
- Calcium signaling
- Epithelial cell
- Na,K-ATPase
- Store-operated calcium entry
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology