Abstract
The direct enantioselective chiral calcium(ii)·phosphate complex (Ca[CPA]2)-catalyzed conjugate addition of unprotected alkyl amines to maleimides was developed. This mild catalytic system represents a significant advance towards the general convergent asymmetric amination of α,β-unsaturated electrophiles, providing medicinally relevant chiral aminosuccinimide products in high yields and enantioselectivities. Furthermore, the catalyst can be reused directly from a previously chromatographed reaction and still maintain both high yield and selectivity.
Original language | English (US) |
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Pages (from-to) | 1634-1639 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - 2018 |
ASJC Scopus subject areas
- General Chemistry
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CCDC 1531303: Experimental Crystal Structure Determination
Uno, B. E. (Creator), Dicken, R. D. (Creator), Redfern, L. R. (Creator), Stern, C. M. (Creator), Krzywicki, G. G. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1ndfwc, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1ndfwc&sid=DataCite
Dataset
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CCDC 1531265: Experimental Crystal Structure Determination
Uno, B. E. (Creator), Dicken, R. D. (Creator), Redfern, L. R. (Creator), Stern, C. M. (Creator), Krzywicki, G. G. (Creator) & Scheidt, K. A. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1nddn3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1nddn3&sid=DataCite
Dataset