Calibrating Functional Parameters in the Ion Channel Models of Cardiac Cells

Matthew Plumlee*, V. Roshan Joseph, Hui Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Computational modeling is a popular tool to understand a diverse set of complex systems. The output from a computational model depends on a set of parameters that are unknown to the designer, but a modeler can estimate them by collecting physical data. In the described study of the ion channels of ventricular myocytes, the parameter of interest is a function as opposed to a scalar or a set of scalars. This article develops a new modeling strategy to nonparametrically study the functional parameter using Bayesian inference with Gaussian process prior distributions. A new sampling scheme is devised to address this unique problem.

Original languageEnglish (US)
Pages (from-to)500-509
Number of pages10
JournalJournal of the American Statistical Association
Issue number514
StatePublished - Apr 2 2016


  • Calibration
  • Computer experiment
  • Functional response
  • High-dimensional parameters
  • Simulation experiment

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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