Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young; Deborah Mullen; Lewis Landsberg

doi:10.1016/0026-0495(78)90256-1

Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young^*, Deborah Mullen, Lewis Landsberg

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.

Original language	English (US)
Pages (from-to)	1711-1714
Number of pages	4
Journal	Metabolism
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/0026-0495(78)90256-1
State	Published - Dec 1978

Funding

From the Thorndike Laboratory and the Department of Medicine, Harvard Medical School and Beth Israel Hospital, Boston, Mass. Receivedforpublication March 16, 1978. Supported in part by USPHS Grants AM-20378 and RR-76. Dr. Young is the recipient of USPHS Fellowship AM-05755. Address reprint requests to Dr. James B. Young, Department of Medicine, Beth Israel Hospital, 330 Brookline Avenue, Boston, Mass. 02215. 0 1978 by Grune & Stratton, Inc., 0026-0495/78/27/2-0001$01.00/0

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0026-0495(78)90256-1

Cite this

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title = "Caloric restriction lowers blood pressure in the spontaneously hypertensive rat",

abstract = "In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.",

author = "Young, {James B.} and Deborah Mullen and Lewis Landsberg",

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doi = "10.1016/0026-0495(78)90256-1",

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AB - In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.

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Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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