Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young*, Deborah Mullen, Lewis Landsberg

*Corresponding author for this work

Research output: Contribution to journalArticle

101 Scopus citations


In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.

Original languageEnglish (US)
Pages (from-to)1711-1714
Number of pages4
Issue number12
Publication statusPublished - Dec 1978


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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