Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young*, Deborah Mullen, Lewis Landsberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Scopus citations

Abstract

In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.

Original languageEnglish (US)
Pages (from-to)1711-1714
Number of pages4
JournalMetabolism
Volume27
Issue number12
DOIs
StatePublished - Dec 1978

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint

Dive into the research topics of 'Caloric restriction lowers blood pressure in the spontaneously hypertensive rat'. Together they form a unique fingerprint.

Cite this