Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young; Deborah Mullen; Lewis Landsberg

doi:10.1016/0026-0495(78)90256-1

Caloric restriction lowers blood pressure in the spontaneously hypertensive rat

James B. Young^*, Deborah Mullen, Lewis Landsberg

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.

Original language	English (US)
Pages (from-to)	1711-1714
Number of pages	4
Journal	Metabolism
Volume	27
Issue number	12
DOIs	https://doi.org/10.1016/0026-0495(78)90256-1
State	Published - Dec 1978

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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abstract = "In the spontaneously hypertensive rat (SHR), caloric restriction without sodium restriction is associated with reduced blood pressure. Four days of fasting lowered blood pressure 19% while 4 days of eating 50% of ad lib intake reduced blood pressure 10%. Similar dietary changes had less effect on blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). These data are consistent with the hypothesis that caloric restriction lowers sympathetic activity.",

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