Can blood group O red cells of donor origin acquire weak group A reactivity through serum A transferase of the recipient after bone marrow transplantation?

M. G. Wichmann*, T. Haferlach, M. Suttorp, Y. Zhang, J. Neppert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Blood group A substance was detected on red cells of a patient who received a bone marrow transplant from a blood group O donor 3.5 years ago. Material and Methods: Peripheral blood was investigated by conventional serological techniques, fluorescence in situ hybridisation, and polymerase chain reaction. Results: All peripheral blood cells are of donor origin. Anti-A and not anti-A,B of blood group O individuals can be absorbed to the group O red cells of the patient. Conclusion: We suppose that the patient's residual serum A transferase attaches the appropriate sugar to substance H on the red cell membrane to form substance A.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalInfusionstherapie und Transfusionsmedizin
Volume23
Issue number1
StatePublished - Feb 1996

Keywords

  • Blood typing
  • Bone marrow transplantation
  • Transferase

ASJC Scopus subject areas

  • Food Science
  • Immunology
  • Hematology

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