Can macrophages cause obstruction to aqueous outflow in rabbits?

Robert S. Feder, David K. Dueker

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We describe a technique by which large numbers of peritoneal macrophages can be harvested without harming the experimental animal. The macrophages can be reintroduced into the same animal avoiding possible immune reactions associated with injection of foreign cells or other antigenic materials. In an attempt to obstruct aqueous outflow rabbit peritoneal macrophages engorged with mineral oil were injected intracamerally in the same rabbit's eye. The number of cells per single injection varied from 4.0 × 104 to 1.4 × 106 in eight rabbits. In three animals daily injections of 1 × 106 cells were performed. Using the Perkins applanation tonometer daily and hourly, no pressure elevation could be detected.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalInternational Ophthalmology
Volume7
Issue number2
DOIs
StatePublished - Jun 1 1984

Keywords

  • Perkins tonometer
  • ghost cell glaucoma
  • macrophage
  • outflow obstruction
  • phacolytic glaucoma

ASJC Scopus subject areas

  • Ophthalmology

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