Can Multivalency Be Expressed Kinetically? The Answer Is Yes

Jovica D. Badjić, Stuart J. Cantrill, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Inspired by the concept of multivalency and in pursuit of ever more intricate artificial molecular machines, we investigated the strict self-assembly of a triply threaded two-component superbundle, starting from a tritopic receptor in which three benzo[24]crown-8 macrorings are fused onto a triphenylene core and a trifurcated trication wherein three bipyridinium units are linked 1,3,5 to a central benzenoid core. The result of the investigation was quite unexpected and surprising. It transpired that the rapid formation of a doubly threaded two-component complex was followed by an extremely slow conversion (a week at 253 K in CD3COCD3 to reach equilibrium) of this kinetically controlled product into a thermodynamically controlled one, namely a triply threaded two-component superbundle. This intriguing observation begs the question: are there instances in nature where multivalency is expressed as a kinetically controlled process, prior to an equilibrium state being reached, and if so, what are the biological implications, if any?

Original languageEnglish (US)
Pages (from-to)2288-2289
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number8
DOIs
StatePublished - Mar 3 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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