Can primary pulmonary hypertension be treated effectively?

M. B. Seidlitz*, S. Rich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Until recently, primary pulmonary hypertension had been untreatable, progressing to death shortly after diagnosis. Investigators have defined a subset of patients who respond to large doses of calcium-channel blockers with a sustained decrease in mean pulmonary artery pressure, pulmonary vascular resistance and increase in cardiac output. Along with improvement in hemodynamic parameters, survival is prolonged markedly, right ventricular hypertrophy is reduced and functional status is improved. Patients who did not respond to high-dose calcium-channel blockers appeared to derive survival benefit from anticoagulation therapy. Determining response to calcium-channel blockers requires careful hemodynamic monitoring to avoid potentially adverse responses.

Original languageEnglish (US)
Pages (from-to)48-50
Number of pages3
JournalChoices in Cardiology
Issue number2
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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