Cancer and Systemic Lupus Erythematosus

Alexandra Ladouceur, Basile Tessier-Cloutier, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen, Sasha Bernatsky*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Systemic lupus erythematosus is associated with a small overall increased cancer risk compared with the general population. This risk includes a 4-fold increased risk of non-Hodgkin lymphoma, but a decreased risk of other cancers (such as breast cancer). The pathophysiology underlying the increased risk of hematologic cancer is not fully understood, but many potential mechanisms have been proposed, including dysfunction of the tumor necrosis factor and other pathways. A decreased risk of breast, ovarian, and endometrial cancer might be driven by hormonal factors or lupus-related antibodies, but these links have not been proved.

Original languageEnglish (US)
Pages (from-to)533-550
Number of pages18
JournalRheumatic Disease Clinics of North America
Volume46
Issue number3
DOIs
StatePublished - Aug 2020

Keywords

  • Cancer
  • Epidemiology
  • Malignancy
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

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