Cancer-associated thrombosis: Regulatory mechanisms and emerging directions

Alice Prodger, Prakash Saha, Alberto Smith, Colin E. Evans*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Venous thrombosis is a common complication in cancer patients, and some cancer chemotherapies are associated with an increased risk of venous thromboembolism. The regulatory mechanisms that control thrombus formation and subsequent resolution in patients with cancer, however, are incompletely understood, and novel treatments for cancerassociated thrombosis may arise from a better understanding of such mechanisms. In this chapter, pathways that regulate cancer-associated thrombus formation are outlined, and the effects of anti-angiogenic cancer chemotherapies on venous thrombus resolution are highlighted. Potentially pro-thrombotic effects of anti-angiogenic agents are important considerations when managing the complications of venous thrombosis in cancer patients.

Original languageEnglish (US)
JournalAdvances in experimental medicine and biology
Volume906
DOIs
StatePublished - Jan 1 2017

Keywords

  • Anti-angiogenic
  • Cancer
  • Chemotherapy
  • Hypoxia
  • Resolution
  • Thrombosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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