Cancer cell death by design: Apoptosis, autophagy and glioma virotherapy

Matthew A. Tyler, Ilya V. Ulasov, Maciej S. Lesniak

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

Autophagy has been defined as a mechanism by which oncolytic adenoviruses mediate cell killing in some cancers, including malignant glioma. Until recently, however, adenovirus replication was regarded as a process that induced classical apoptosis in the infected cell. We have assessed the method of conditionally replicating adenovirus (CRAd) death in a model of malignant glioma, considering both autophagy and apoptosis as possible mechanisms of virally-induced cell death. Our initial investigations indicated that autophagy was the predominant system in CRAd-induced cell death in glioma. This appeared to be the case in vitro; however, further investigation in vivo shows that CRAds are capable of inducing both apoptotic and autophagic cell death. In this punctum, we summarize our latest research to uncover the method of oncolytic adenovirus-induced cell death in malignant glioma. Elucidating the relationship between autophagy and apoptosis in glioma virotherapy has significant implications for the design of optimal viral vectors.

Original languageEnglish (US)
Pages (from-to)856-857
Number of pages2
JournalAutophagy
Volume5
Issue number6
DOIs
StatePublished - Aug 16 2009

Fingerprint

Autophagy
Adenoviridae
Glioma
Cell Death
Apoptosis
Neoplasms
Research

Keywords

  • Adenovirus
  • Apoptosis
  • Autophagy
  • Cell death
  • Gene therapy
  • Glioma
  • Survivin
  • Temozolomide
  • Virotherapy

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Tyler, Matthew A. ; Ulasov, Ilya V. ; Lesniak, Maciej S. / Cancer cell death by design : Apoptosis, autophagy and glioma virotherapy. In: Autophagy. 2009 ; Vol. 5, No. 6. pp. 856-857.
@article{9dbe7c4cb345450e9ff01c0c1efae22b,
title = "Cancer cell death by design: Apoptosis, autophagy and glioma virotherapy",
abstract = "Autophagy has been defined as a mechanism by which oncolytic adenoviruses mediate cell killing in some cancers, including malignant glioma. Until recently, however, adenovirus replication was regarded as a process that induced classical apoptosis in the infected cell. We have assessed the method of conditionally replicating adenovirus (CRAd) death in a model of malignant glioma, considering both autophagy and apoptosis as possible mechanisms of virally-induced cell death. Our initial investigations indicated that autophagy was the predominant system in CRAd-induced cell death in glioma. This appeared to be the case in vitro; however, further investigation in vivo shows that CRAds are capable of inducing both apoptotic and autophagic cell death. In this punctum, we summarize our latest research to uncover the method of oncolytic adenovirus-induced cell death in malignant glioma. Elucidating the relationship between autophagy and apoptosis in glioma virotherapy has significant implications for the design of optimal viral vectors.",
keywords = "Adenovirus, Apoptosis, Autophagy, Cell death, Gene therapy, Glioma, Survivin, Temozolomide, Virotherapy",
author = "Tyler, {Matthew A.} and Ulasov, {Ilya V.} and Lesniak, {Maciej S.}",
year = "2009",
month = "8",
day = "16",
doi = "10.4161/auto.8792",
language = "English (US)",
volume = "5",
pages = "856--857",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "6",

}

Cancer cell death by design : Apoptosis, autophagy and glioma virotherapy. / Tyler, Matthew A.; Ulasov, Ilya V.; Lesniak, Maciej S.

In: Autophagy, Vol. 5, No. 6, 16.08.2009, p. 856-857.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Cancer cell death by design

T2 - Apoptosis, autophagy and glioma virotherapy

AU - Tyler, Matthew A.

AU - Ulasov, Ilya V.

AU - Lesniak, Maciej S.

PY - 2009/8/16

Y1 - 2009/8/16

N2 - Autophagy has been defined as a mechanism by which oncolytic adenoviruses mediate cell killing in some cancers, including malignant glioma. Until recently, however, adenovirus replication was regarded as a process that induced classical apoptosis in the infected cell. We have assessed the method of conditionally replicating adenovirus (CRAd) death in a model of malignant glioma, considering both autophagy and apoptosis as possible mechanisms of virally-induced cell death. Our initial investigations indicated that autophagy was the predominant system in CRAd-induced cell death in glioma. This appeared to be the case in vitro; however, further investigation in vivo shows that CRAds are capable of inducing both apoptotic and autophagic cell death. In this punctum, we summarize our latest research to uncover the method of oncolytic adenovirus-induced cell death in malignant glioma. Elucidating the relationship between autophagy and apoptosis in glioma virotherapy has significant implications for the design of optimal viral vectors.

AB - Autophagy has been defined as a mechanism by which oncolytic adenoviruses mediate cell killing in some cancers, including malignant glioma. Until recently, however, adenovirus replication was regarded as a process that induced classical apoptosis in the infected cell. We have assessed the method of conditionally replicating adenovirus (CRAd) death in a model of malignant glioma, considering both autophagy and apoptosis as possible mechanisms of virally-induced cell death. Our initial investigations indicated that autophagy was the predominant system in CRAd-induced cell death in glioma. This appeared to be the case in vitro; however, further investigation in vivo shows that CRAds are capable of inducing both apoptotic and autophagic cell death. In this punctum, we summarize our latest research to uncover the method of oncolytic adenovirus-induced cell death in malignant glioma. Elucidating the relationship between autophagy and apoptosis in glioma virotherapy has significant implications for the design of optimal viral vectors.

KW - Adenovirus

KW - Apoptosis

KW - Autophagy

KW - Cell death

KW - Gene therapy

KW - Glioma

KW - Survivin

KW - Temozolomide

KW - Virotherapy

UR - http://www.scopus.com/inward/record.url?scp=69449089962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69449089962&partnerID=8YFLogxK

U2 - 10.4161/auto.8792

DO - 10.4161/auto.8792

M3 - Short survey

C2 - 19430207

AN - SCOPUS:69449089962

VL - 5

SP - 856

EP - 857

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 6

ER -