Cancer metabolism as a therapeutic target

Surabhi Batra, Kehinde Adekola, Steven T. Rosen, Mala Shanmugam

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Cancer is now recognized to be a disease arising from both genetic and metabolic abnormalities. In the mid-1900s, Otto Warburg described the phenomenon of elevated glucose consumption and aerobic glycolysis, and the dependence of cancer cells on this phenomenon for proliferation and growth. The Warburg effect has formed the basis of such diagnostic and prognostic imaging modalities as positron emission tomography (PET); however, we have not yet capitalized on this phenomenon for therapy. Several mechanisms have now been shown to contribute to the Warburg effect.

Original languageEnglish (US)
JournalONCOLOGY (United States)
Volume27
Issue number5
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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