TY - JOUR
T1 - Cancer multidrug resistance
T2 - Mechanisms involved and strategies for circumvention using a drug delivery system
AU - Kibria, Golam
AU - Hatakeyama, Hiroto
AU - Harashima, Hideyoshi
N1 - Funding Information:
Acknowledgments This study was supported in parts by grants from the Special Education and Research Expenses of the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT); Nagai Foundation, Tokyo; as well as by a Grant-in-Aid for Research on Medical Device Development from the Ministry of Health, Labour and Welfare of Japan (MHLW).
PY - 2014/1
Y1 - 2014/1
N2 - Multidrug resistance (MDR), the principal mechanism by which many cancers develop resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment of various types of cancer. Several key regulators are responsible for mediating MDR, a process that renders chemotherapeutic drugs ineffective in the internal organelles of target cells. A nanoparticulate drug delivery system (DDS) is a potentially promising tool for circumventing such MDR, which can be achieved by targeting tumor cells themselves or tumor endothelial cells that support the survival of MDR cancer cells. The present article discusses key factors that are responsible for MDR in cancer cells, with a specific focus on the application of DDS to overcome MDR via the use of chemotherapy or macromolecules.
AB - Multidrug resistance (MDR), the principal mechanism by which many cancers develop resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment of various types of cancer. Several key regulators are responsible for mediating MDR, a process that renders chemotherapeutic drugs ineffective in the internal organelles of target cells. A nanoparticulate drug delivery system (DDS) is a potentially promising tool for circumventing such MDR, which can be achieved by targeting tumor cells themselves or tumor endothelial cells that support the survival of MDR cancer cells. The present article discusses key factors that are responsible for MDR in cancer cells, with a specific focus on the application of DDS to overcome MDR via the use of chemotherapy or macromolecules.
KW - Cancer multidrug resistance (MDR)
KW - Drug delivery system
KW - Key regulators
KW - Reversal of MDR
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U2 - 10.1007/s12272-013-0276-2
DO - 10.1007/s12272-013-0276-2
M3 - Review article
C2 - 24272889
AN - SCOPUS:84892937676
SN - 0253-6269
VL - 37
SP - 4
EP - 15
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 1
ER -
