Cancer multidrug resistance: Mechanisms involved and strategies for circumvention using a drug delivery system

Golam Kibria, Hiroto Hatakeyama, Hideyoshi Harashima*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations

Abstract

Multidrug resistance (MDR), the principal mechanism by which many cancers develop resistance to chemotherapy, is one of the major obstacles to the successful clinical treatment of various types of cancer. Several key regulators are responsible for mediating MDR, a process that renders chemotherapeutic drugs ineffective in the internal organelles of target cells. A nanoparticulate drug delivery system (DDS) is a potentially promising tool for circumventing such MDR, which can be achieved by targeting tumor cells themselves or tumor endothelial cells that support the survival of MDR cancer cells. The present article discusses key factors that are responsible for MDR in cancer cells, with a specific focus on the application of DDS to overcome MDR via the use of chemotherapy or macromolecules.

Original languageEnglish (US)
Pages (from-to)4-15
Number of pages12
JournalArchives of Pharmacal Research
Volume37
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Cancer multidrug resistance (MDR)
  • Drug delivery system
  • Key regulators
  • Reversal of MDR

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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