Cancer stem cells and glioma

Sunit Das*, Maya Srikanth, John Kessler

*Corresponding author for this work

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

Despite continued advances in surgical and medical therapies, the outcomes for patients diagnosed with glioblastoma multiforme remain dismal. Recent data suggest that progression of these brain tumors is driven by a small subpopulation of tumor cells, which are termed cancer stem cells (CSCs) because of their capability to self-renew, proliferate and give rise to progeny of multiple neuroepithelial lineages. According to the CSC hypothesis, current therapies that are extremely cytotoxic to the bulk of highly proliferative tumor cells fail to obliterate the relatively quiescent and resistant CSC compartment, thereby allowing these cells to survive and drive tumor recurrence. This Review summarizes current knowledge regarding neural stem cells in the normal adult brain and CSCs in glial tumors and discusses the implications of the CSC hypothesis for the development of future therapies for brain tumors.

Original languageEnglish (US)
Pages (from-to)427-435
Number of pages9
JournalNature Clinical Practice Neurology
Volume4
Issue number8
DOIs
StatePublished - Jul 16 2008

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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