TY - JOUR
T1 - Canine liver transplantation under nva cyclosporine versus cyclosporine
AU - Todo, Satoru
AU - Porter, Kendrick A.
AU - Kam, Igal
AU - Lynch, Stephen
AU - Venkataramanan, Raman
AU - DeWolf, Andre
AU - Starzl, Thomas E.
PY - 1986/3
Y1 - 1986/3
N2 - The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva 2-CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva 2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva2-CsA. Histopathologically, Nva2-CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva2-CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney.
AB - The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva 2-CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva 2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva2-CsA. Histopathologically, Nva2-CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva2-CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney.
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U2 - 10.1097/00007890-198603000-00004
DO - 10.1097/00007890-198603000-00004
M3 - Article
C2 - 3513388
AN - SCOPUS:0022642896
SN - 0041-1337
VL - 41
SP - 296
EP - 300
JO - Transplantation
JF - Transplantation
IS - 3
ER -