Canine model of stable chronic heart failure

M. Takagaki*, K. Fukamachi, P. M. McCarthy, T. Tabata, L. A. Cardon, Y. Ochiai, R. Dessoffy, J. D. Thomas

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


To establish a stable chronic model for long-term use, heart failure was induced in five mongrel dogs by pacing at 230 bpm for four weeks, performing sham operation, and pacing at 190 bpm for another four weeks. Furosemide was given postoperatively for four weeks. Hemodynamics and 2-dimensional echocardiographic data during transient cessation of pacing at Week four and Week eight were compared with those from 18 normal dogs. Overall, hear failure induction at 230 bpm for four weeks gave a very stable and adequate level of heart failure in animals.

Original languageEnglish (US)
Pages (from-to)178
Number of pages1
JournalASAIO Journal
Issue number2
StatePublished - 2000
Event46th Annual Conference and Exposition of ASAIO - New York, NY, USA
Duration: Jun 28 2000Jul 1 2000

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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