Canonical Motor Microcircuit for Control of a Rat Hindlimb

Clayton Jackson; William R.P. Nourse; C. J. Heckman; Matthew Tresch; Roger D. Quinn

doi:10.1007/978-3-031-20470-8_31

Canonical Motor Microcircuit for Control of a Rat Hindlimb

Clayton Jackson^*, William R.P. Nourse, C. J. Heckman, Matthew Tresch, Roger D. Quinn

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This work focuses on creating a controller for the hip joint of a rat using a canonical motor microcircuit. It is thought that this circuit acts to modulate motor neuron activity at the output stage. We first created a simplified biomechanical model of a rat hindlimb along with a neural model of the circuit in a software tool called Animatlab. The canonical motor microcircuit controller was then tuned such that the trajectory of the hip joint was similar to that of a rat during locomotion. This work describes a successful method for hand-tuning the various synaptic parameters and the influence of Ia feedback on motor neuron activity. The neuromechanical model will allow for further analysis of the circuit, specifically, the function and significance of Ia feedback and Renshaw cells.

Original language	English (US)
Title of host publication	Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings
Editors	Alexander Hunt, Vasiliki Vouloutsi, Kenneth Moses, Roger Quinn, Anna Mura, Tony Prescott, Paul F. Verschure
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	309-320
Number of pages	12
ISBN (Print)	9783031204692
DOIs	https://doi.org/10.1007/978-3-031-20470-8_31
State	Published - 2022
Event	11th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022 - Virtual, Online Duration: Jul 19 2022 → Jul 22 2022

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	13548 LNAI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	11th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022
City	Virtual, Online
Period	7/19/22 → 7/22/22

Keywords

Canonical Motor Microcircuit
Neuromechanical simulation
Rat
Renshaw cells

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/978-3-031-20470-8_31

Cite this

Jackson, C., Nourse, W. R. P., Heckman, C. J., Tresch, M., & Quinn, R. D. (2022). Canonical Motor Microcircuit for Control of a Rat Hindlimb. In A. Hunt, V. Vouloutsi, K. Moses, R. Quinn, A. Mura, T. Prescott, & P. F. Verschure (Eds.), Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings (pp. 309-320). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13548 LNAI). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-20470-8_31

Jackson, Clayton ; Nourse, William R.P. ; Heckman, C. J. et al. / Canonical Motor Microcircuit for Control of a Rat Hindlimb. Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings. editor / Alexander Hunt ; Vasiliki Vouloutsi ; Kenneth Moses ; Roger Quinn ; Anna Mura ; Tony Prescott ; Paul F. Verschure. Springer Science and Business Media Deutschland GmbH, 2022. pp. 309-320 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Jackson, C, Nourse, WRP, Heckman, CJ , Tresch, M & Quinn, RD 2022, Canonical Motor Microcircuit for Control of a Rat Hindlimb. in A Hunt, V Vouloutsi, K Moses, R Quinn, A Mura, T Prescott & PF Verschure (eds), Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 13548 LNAI, Springer Science and Business Media Deutschland GmbH, pp. 309-320, 11th International Conference on Biomimetic and Biohybrid Systems, Living Machines 2022, Virtual, Online, 7/19/22. https://doi.org/10.1007/978-3-031-20470-8_31

Canonical Motor Microcircuit for Control of a Rat Hindlimb. / Jackson, Clayton; Nourse, William R.P.; Heckman, C. J. et al.

Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings. ed. / Alexander Hunt; Vasiliki Vouloutsi; Kenneth Moses; Roger Quinn; Anna Mura; Tony Prescott; Paul F. Verschure. Springer Science and Business Media Deutschland GmbH, 2022. p. 309-320 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 13548 LNAI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Jackson C, Nourse WRP, Heckman CJ , Tresch M, Quinn RD. Canonical Motor Microcircuit for Control of a Rat Hindlimb. In Hunt A, Vouloutsi V, Moses K, Quinn R, Mura A, Prescott T, Verschure PF, editors, Biomimetic and Biohybrid Systems - 11th International Conference, Living Machines 2022, Proceedings. Springer Science and Business Media Deutschland GmbH. 2022. p. 309-320. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-031-20470-8_31