Cap polyposis with protein-losing enteropathy

This case study is the ninth case reported since the last large series in 2003. Before establishing the diagnosis of cap polyposis, 4 of the 9 patients were initially diagnosed with ulcerative colitis and 1 patient was diagnosed with mucosal prolapse syndrome. Upon treatment, 4 of the 9 patients were treated for H. pylori infection, which resulted in the eradication of their gastritis and polyps. Resolution of cap polyposis was experienced after infliximab (Remicade, Centocor) in 1 patient, polypectomy in another patient, and total colectomy in a third patient; a fourth patient experienced complete resolution without any treatment. Many researchers attribute cap polyposis to mucosal prolapse syndrome; however, the exact mechanism of the underlying cause and the appropriate treatment strategy have not yet been elucidated.