Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

Hui Fang, Ki Jun Yu, Christopher Gloschat, Zijian Yang, Enming Song, Chia Han Chiang, Jianing Zhao, Sang Min Won, Siyi Xu, Michael Trumpis, Yiding Zhong, Seung Won Han, Yeguang Xue, Dong Xu, Seo Woo Choi, Gert Cauwenberghs, Matthew Kay, Yonggang Huang, Jonathan Viventi, Igor R. Efimov & 1 others John A Rogers

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro-physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.

Original languageEnglish (US)
Article number0038
JournalNature Biomedical Engineering
Volume1
Issue number3
DOIs
StatePublished - Mar 9 2017

Fingerprint

Cardiac Electrophysiology
Flexible electronics
Silicon
Transistors
Electronic equipment
Leakage currents
Seals
Technology
Metals
Tissue
Fluids
Heart Diseases
Safety

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

Fang, Hui ; Yu, Ki Jun ; Gloschat, Christopher ; Yang, Zijian ; Song, Enming ; Chiang, Chia Han ; Zhao, Jianing ; Won, Sang Min ; Xu, Siyi ; Trumpis, Michael ; Zhong, Yiding ; Han, Seung Won ; Xue, Yeguang ; Xu, Dong ; Choi, Seo Woo ; Cauwenberghs, Gert ; Kay, Matthew ; Huang, Yonggang ; Viventi, Jonathan ; Efimov, Igor R. ; Rogers, John A. / Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology. In: Nature Biomedical Engineering. 2017 ; Vol. 1, No. 3.
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Fang, H, Yu, KJ, Gloschat, C, Yang, Z, Song, E, Chiang, CH, Zhao, J, Won, SM, Xu, S, Trumpis, M, Zhong, Y, Han, SW, Xue, Y, Xu, D, Choi, SW, Cauwenberghs, G, Kay, M, Huang, Y, Viventi, J, Efimov, IR & Rogers, JA 2017, 'Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology', Nature Biomedical Engineering, vol. 1, no. 3, 0038. https://doi.org/10.1038/s41551-017-0038

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology. / Fang, Hui; Yu, Ki Jun; Gloschat, Christopher; Yang, Zijian; Song, Enming; Chiang, Chia Han; Zhao, Jianing; Won, Sang Min; Xu, Siyi; Trumpis, Michael; Zhong, Yiding; Han, Seung Won; Xue, Yeguang; Xu, Dong; Choi, Seo Woo; Cauwenberghs, Gert; Kay, Matthew; Huang, Yonggang; Viventi, Jonathan; Efimov, Igor R.; Rogers, John A.

In: Nature Biomedical Engineering, Vol. 1, No. 3, 0038, 09.03.2017.

Research output: Contribution to journalArticle

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AU - Song, Enming

AU - Chiang, Chia Han

AU - Zhao, Jianing

AU - Won, Sang Min

AU - Xu, Siyi

AU - Trumpis, Michael

AU - Zhong, Yiding

AU - Han, Seung Won

AU - Xue, Yeguang

AU - Xu, Dong

AU - Choi, Seo Woo

AU - Cauwenberghs, Gert

AU - Kay, Matthew

AU - Huang, Yonggang

AU - Viventi, Jonathan

AU - Efimov, Igor R.

AU - Rogers, John A

PY - 2017/3/9

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N2 - Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro-physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.

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