Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

Pinghuang Liu; La Tonya D. Williams; Xiaoying Shen; Mattia Bonsignori; Nathan A. Vandergrift; R. Glenn Overman; M. Anthony Moody; Hua Xin Liao; Daniel J. Stieh; Kerrie L. McCotter; Audrey L. French; Thomas J. Hope; Robin Shattock; Barton F. Haynes; Georgia D. Tomaras

doi:10.1128/JVI.03765-13

Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

Pinghuang Liu, La Tonya D. Williams, Xiaoying Shen, Mattia Bonsignori, Nathan A. Vandergrift, R. Glenn Overman, M. Anthony Moody, Hua Xin Liao, Daniel J. Stieh, Kerrie L. McCotter, Audrey L. French, Thomas J. Hope, Robin Shattock, Barton F. Haynes, Georgia D. Tomaras^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.

Original language	English (US)
Pages (from-to)	5165-5170
Number of pages	6
Journal	Journal of virology
Volume	88
Issue number	9
DOIs	https://doi.org/10.1128/JVI.03765-13
State	Published - May 2014

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/JVI.03765-13

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Liu, P., Williams, L. T. D., Shen, X., Bonsignori, M., Vandergrift, N. A., Overman, R. G., Moody, M. A., Liao, H. X., Stieh, D. J., McCotter, K. L., French, A. L., Hope, T. J., Shattock, R., Haynes, B. F., & Tomaras, G. D. (2014). Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity. Journal of virology, 88(9), 5165-5170. https://doi.org/10.1128/JVI.03765-13

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abstract = "Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.",

author = "Pinghuang Liu and Williams, {La Tonya D.} and Xiaoying Shen and Mattia Bonsignori and Vandergrift, {Nathan A.} and Overman, {R. Glenn} and Moody, {M. Anthony} and Liao, {Hua Xin} and Stieh, {Daniel J.} and McCotter, {Kerrie L.} and French, {Audrey L.} and Hope, {Thomas J.} and Robin Shattock and Haynes, {Barton F.} and Tomaras, {Georgia D.}",

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AU - Liu, Pinghuang

AU - Williams, La Tonya D.

AU - Shen, Xiaoying

AU - Bonsignori, Mattia

AU - Vandergrift, Nathan A.

AU - Overman, R. Glenn

AU - Moody, M. Anthony

AU - Liao, Hua Xin

AU - Stieh, Daniel J.

AU - McCotter, Kerrie L.

AU - French, Audrey L.

AU - Hope, Thomas J.

AU - Shattock, Robin

AU - Haynes, Barton F.

AU - Tomaras, Georgia D.

PY - 2014/5

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AB - Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.

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Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity

Abstract

ASJC Scopus subject areas

UN SDGs

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