Thirteen courses of carbenicillin were given to ten children with cystic fibrosis and pulmonary infections due to Pseudomonas aeruginosa. There was clinical improvement following antimicrobial therapy in seven children; however, four children ultimately died. Carbenicillin alone or in combination with polymyxin B sulfate or gentamicin sulfate did not eradicate P aeruginosa from the sputum. There was poor correlation of the clinical result of therapy with the susceptibility of the infecting organism. The only adverse result of carbenicillin administration was a reversible rise in serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase noted during therapy.
|Original language||English (US)|
|Number of pages||4|
|Journal||American Journal of Diseases of Children|
|State||Published - Jul 1970|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health