Abstract
Thirteen courses of carbenicillin were given to ten children with cystic fibrosis and pulmonary infections due to Pseudomonas aeruginosa. There was clinical improvement following antimicrobial therapy in seven children; however, four children ultimately died. Carbenicillin alone or in combination with polymyxin B sulfate or gentamicin sulfate did not eradicate P aeruginosa from the sputum. There was poor correlation of the clinical result of therapy with the susceptibility of the infecting organism. The only adverse result of carbenicillin administration was a reversible rise in serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase noted during therapy.
Original language | English (US) |
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Pages (from-to) | 22-25 |
Number of pages | 4 |
Journal | American Journal of Diseases of Children |
Volume | 120 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1970 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health