Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy

Boyd E. Metzger; Roger H. Unger; Norbert Freinkel

doi:10.1016/0026-0495(77)90050-6

Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy

Boyd E. Metzger^*, Roger H. Unger, Norbert Freinkel

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a "mixed meal" containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6-8 wk postpartum. The "mixed meal" elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is "facilitated" during late human pregnancy.

Original language	English (US)
Pages (from-to)	151-156
Number of pages	6
Journal	Metabolism
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/0026-0495(77)90050-6
State	Published - Feb 1977

Funding

From the Center for Endocrinology, Metabolism, and Nutrition, Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Ill., and the Department of Internal Medicine, University of Texas (Southwestern) Medical School and Veterans Administration Hospital. Dallas, Tex. Received for publication April 9. 1976. Supported in part by Research Grants A M-10699 and AM-02700, and Training Grant AM-05071 from the National Institute of Arthritis, Metabolism and Digestive Diseases, by Clinical Research Center Grant RR-48 from the Division of Research Resources, NIH, and a grant from the Kroc Foundation. Reprint requests should be addressed to Dr. Boyd E. Metzger, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, Ill. 60611. B I977 by Grune & Stratton. Inc.

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0026-0495(77)90050-6

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title = "Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a {"}mixed meal{"} in late pregnancy",

abstract = "Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a {"}mixed meal{"} containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6-8 wk postpartum. The {"}mixed meal{"} elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is {"}facilitated{"} during late human pregnancy.",

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note = "Funding Information: From the Center for Endocrinology, Metabolism, and Nutrition, Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Ill., and the Department of Internal Medicine, University of Texas (Southwestern) Medical School and Veterans Administration Hospital. Dallas, Tex. Received for publication April 9. 1976. Supported in part by Research Grants A M-10699 and AM-02700, and Training Grant AM-05071 from the National Institute of Arthritis, Metabolism and Digestive Diseases, by Clinical Research Center Grant RR-48 from the Division of Research Resources, NIH, and a grant from the Kroc Foundation. Reprint requests should be addressed to Dr. Boyd E. Metzger, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, Ill. 60611. B I977 by Grune & Stratton. Inc.",

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N2 - Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a "mixed meal" containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6-8 wk postpartum. The "mixed meal" elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is "facilitated" during late human pregnancy.

AB - Gestational influences upon the changes in circulating glucose, amino acids, insulin, and glucagon after the ingestion of a "mixed meal" containing carbohydrate (50 g), protein (25 g), and fat (10 g) were examined. Nine subjects were tested during weeks 30-40 of gestation and again 6-8 wk postpartum. The "mixed meal" elicited greater and more prolonged increases in plasma glucose antepartum, whereas the increments in total serum amino acids were blunted at all time points. In the face of greater glycemic but lesser aminogenic stimulation, the integrated increase in plasma insulin was 60% greater antepartum than post partum, whereas the increment in glucagon was not significantly altered. Thus, integrated insulin/glucagon response was increased during antepartum studies. The insulin preponderance following alimentary challenge with mixed nutrients would suggest that the anabolism of ingested amino acids is "facilitated" during late human pregnancy.

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Carbohydrate metabolism in pregnancy. XIV. Relationships between circulating glucagon, insulin, glucose and amino acids in response to a "mixed meal" in late pregnancy

Abstract

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ASJC Scopus subject areas

UN SDGs

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