Carbohydrate metabolism in pregnancy. Xv. plasma cpeptide during intravenous glucose tolerance in neonates from normal and insulin-treated diabetic mothers

Richard L. Phelps*, Norbert Freinkel, Arthur H. Rubenstein, Hideshi Kuzuya, Boyd E. Metzger, John J. Boehm, Lars Mølstedpedersen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Basal values for C-peptide and the responses to intravenous glucose have been examined 2-4 h after birth in nine infants from normal and nine infants from diabetic mothers (IDM) (including eight who were being treated with insulin antepartum). Potentially cross-reacting antibody-bound proinsulin was removed prior to C-peptide estimations. Values for basal plasma glucose and fractional rates of glucose disposition (Kt) were inversely correlated in normal and IDM. Mean basal plasma glucose levels were significantly lower in the IDM. Although basal Cpeptide values did not differ significantly in the two groups, C-peptide/glucose ratios were significantly higher in IDM. After glucose administration, C-peptide and immunoreactive insulin increased in parallel in the normal infants, with peak values for both peptides being observed in the late plasma specimens. In contrast, in five IDM, maximal increments in C-peptide occurred in the earliest plasma specimen secured after glucose administration, i.e., at +2 or +10 min. Values for Kt in these five IDM exceeded the highest rates found in the other IDM and in the normal infants. For the IDM, but not the normal infants, basal C-peptide correlated with the net increments in plasma C-peptide during the first 10 min after glucose administration, and the 10-min Cpeptide increments correlated with Kt. These relationships suggest that the augmented basal β cell function in the offspring of some insulin-treated mothers may contribute, at least in part, to their heightened acute secretory capacity for insulin and that the greater acute islet responsiveness may, in turn, be linked to their increased capacity for glucose disposition. and; 1978 BY THE ENDOCRINE SOCIETY.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume46
Issue number1
DOIs
StatePublished - Jan 1978

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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