Carbohydrate metabolism in pregnancy. XVII. Diurnal profiles of plasma glucose, insulin, free fatty acids, triglycerides, cholesterol, and individual amino acids in late normal pregnancy

Richard L. Phelps*, Boyd E. Metzger, Norbert Freinkel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

Diurnal profiles have been constructed for glucose, free fatty acids (FFA), triglycerides, cholesterol, and ten neutral amino acids in subjects with normal carbohydrate metabolism during late pregnancy and in age- and weight-matched nongravid women. Samples of blood were secured during a 24 hour period while the subjects were receiving a liquid formula diet (containing 2,110 kcal with 275 gm carbohydrate and 75 gm protein) in three equal feedings at 0800, 1300, and 1800 hours. Postprandial excursions for most nutrients, as well as plasma concentrations after overnight fast and before each meal, were significantly different in the pregnant subjects. The studies indicate that criteria of normalcy based on observations in nongravid women cannot be invoked to assess fuel homeostasis in late pregnancy, and that separate criteria are necessary to evaluate nutrient regulation at this time.

Original languageEnglish (US)
Pages (from-to)730-736
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Volume140
Issue number7
DOIs
StatePublished - Aug 1 1981

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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