Carcinogenicity of 2,2'-dihydroxy-di-n-propylnitrosamine in the tree shrew (Tupaia glis): Light and electron microscopic features of pulmonary adenomas

Sambasiva Rao Musunuri, Janardan K Reddy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The carcinogenic effect of 2,2'-dihydroxy-di-n-propyinitrosamine (DHPN) was examined in the primitive primate, tree shrew (Tupaia glis). DHPN was administered at a dose of 250 mg/kg body weight sc once a week for 80 weeks. Between 65 and 102 weeks, 8 of 9 males given DHPN (89%) and 11 of 14 females given DHPN (78%) developed pulmonary adenomas. In 2 DHPN-treated males, in addition to adenomas, bronchioalveolar carcinomas were observed. Transmission electron microscopic examination of pulmonary adenomas from 4 DHPN-treated animals showed that Clara cells were the main components of these tumors. In addition to pulmonary tumors, 9% of the DHPN-treated animals developed squamous cell carcinomas of the skin and hepatocellular carcinomas. None of the 6 controls, which received olive oil alone, developed any tumors.

Original languageEnglish (US)
Pages (from-to)835-840
Number of pages6
JournalJournal of the National Cancer Institute
Volume65
Issue number4
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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