Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the syrian golden hamster

M. Sambasiva Rao*, V. Subbarao, J. D. Prasad, D. G. Scarpelli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 μg/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.

Original languageEnglish (US)
Pages (from-to)1677-1679
Number of pages3
JournalCarcinogenesis
Volume9
Issue number9
DOIs
StatePublished - Sep 1988

ASJC Scopus subject areas

  • Cancer Research

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