Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the syrian golden hamster

M. Sambasiva Rao; V. Subbarao; J. D. Prasad; D. G. Scarpelli

doi:10.1093/carcin/9.9.1677

Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the syrian golden hamster

M. Sambasiva Rao^*, V. Subbarao, J. D. Prasad, D. G. Scarpelli

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 μg/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.

Original language	English (US)
Pages (from-to)	1677-1679
Number of pages	3
Journal	Carcinogenesis
Volume	9
Issue number	9
DOIs	https://doi.org/10.1093/carcin/9.9.1677
State	Published - Sep 1988

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/carcin/9.9.1677

Cite this

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title = "Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the syrian golden hamster",

abstract = "The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 μg/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.",

author = "Rao, {M. Sambasiva} and V. Subbarao and Prasad, {J. D.} and Scarpelli, {D. G.}",

note = "Funding Information: This study is supported in part by the Marie A.Fleming and Edith Patterson Cancer Research Fund, Northwestern University.",

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AU - Rao, M. Sambasiva

AU - Subbarao, V.

AU - Prasad, J. D.

AU - Scarpelli, D. G.

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AB - The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 μg/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.

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Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the syrian golden hamster

Abstract

ASJC Scopus subject areas

UN SDGs

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