Cardiac and intestinal tissue conduct developmental and reparative processes in response to lymphangiocrine signaling

Shreya Kurup, Can Tan*, Tsutomu Kume*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Lymphatic vessels conduct a diverse range of activities to sustain the integrity of surrounding tissue. Besides facilitating the movement of lymph and its associated factors, lymphatic vessels are capable of producing tissue-specific responses to changes within their microenvironment. Lymphatic endothelial cells (LECs) secrete paracrine signals that bind to neighboring cell-receptors, commencing an intracellular signaling cascade that preludes modifications to the organ tissue’s structure and function. While the lymphangiocrine factors and the molecular and cellular mechanisms themselves are specific to the organ tissue, the crosstalk action between LECs and adjacent cells has been highlighted as a commonality in augmenting tissue regeneration within animal models of cardiac and intestinal disease. Lymphangiocrine secretions have been owed for subsequent improvements in organ function by optimizing the clearance of excess tissue fluid and immune cells and stimulating favorable tissue growth, whereas perturbations in lymphatic performance bring about the opposite. Newly published landmark studies have filled gaps in our understanding of cardiac and intestinal maintenance by revealing key players for lymphangiocrine processes. Here, we will expand upon those findings and review the nature of lymphangiocrine factors in the heart and intestine, emphasizing its involvement within an interconnected network that supports daily homeostasis and self-renewal following injury.

Original languageEnglish (US)
Article number1329770
JournalFrontiers in Cell and Developmental Biology
StatePublished - 2023


  • FOXC
  • R-spondins
  • lymphangiocrine factors
  • lymphangiogenesis
  • lymphatic vessel
  • reelin

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology


Dive into the research topics of 'Cardiac and intestinal tissue conduct developmental and reparative processes in response to lymphangiocrine signaling'. Together they form a unique fingerprint.

Cite this