Cardiac Management in Neuromuscular Diseases

Hugh D. Allen*, Philip T. Thrush, Timothy M. Hoffman, Kevin M. Flanigan, Jerry R. Mendell

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

This article addresses the pathophysiology, diagnostic approaches, and therapeutic options in the more common forms of muscular dystrophy, especially those seen in pediatric and young adult populations. The major emphasis is on the dystrophinopathies because their treatment options are templates for those used in various other forms of dystrophy. Most patients with cardiomyopathy are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, with other agents added as the disease progresses. Destination therapies and transplantation options are mentioned where appropriate. Some dystrophies can have significant conduction abnormalities requiring pacemaker treatment. Others with ventricular tachydysrhythmias may necessitate internal cardiac defibrillator placement.

Original languageEnglish (US)
Pages (from-to)855-868
Number of pages14
JournalPhysical Medicine and Rehabilitation Clinics of North America
Volume23
Issue number4
DOIs
StatePublished - Nov 1 2012

Keywords

  • Becker muscular dystrophy
  • Duchenne muscular dystrophy
  • Emery-Dreifuss muscular dystrophy
  • Limb-girdle muscular dystrophy
  • Myotonic muscular dystrophy

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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