Cardiac Structure–Function MRI in Patients After Heart Transplantation

Ryan S. Dolan, Amir A. Rahsepar, Julie Blaisdell, Kai Lin, Kenichiro Suwa, Kambiz Ghafourian, Jane E. Wilcox, Sadiya S. Khan, Esther E. Vorovich, Jonathan D. Rich, Allen S. Anderson, Clyde W. Yancy, Jeremy D. Collins, Michael Markl*, James C. Carr

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Following heart transplantation (Tx), recipients are closely monitored using endomyocardial biopsy, which is limited by cost and invasiveness, and echocardiography, which is limited regarding detailed structural and functional evaluation. Purpose: To test the feasibility of comprehensive structure–function cardiac MRI as a noninvasive modality to assess changes in myocardial structure and function. Study Type: Prospective. Subjects: MR was performed in 61 heart transplant recipients (age 47.9 ± 16.3 years, 39% female) and 14 age-matched healthy controls (age 47.7 ± 16.7 years, 36% female). Field Strength/Sequence: 1.5T; 2D CINE steady state free precession (SSF)P imaging, T 2 -mapping, pre- and postgadolinium contrast T 1 -mapping, and tissue-phase mapping (TPM). Assessment: Quantification of myocardial T 2 (as a measure of edema), pre- and post-Gd T 1 (allowing calculation of extracellular volume (ECV) to estimate interstitial expansion), and TPM-based assessment of peak regional left ventricular (LV) velocities, dyssynchrony, and twist. Statistical Tests: Comparisons between transplant recipients and controls were performed using independent samples t-tests. Relationships between structural (T 2 , T 1 , ECV) and functional measures (myocardial velocities, dyssynchrony, twist) were assessed using Pearson correlation analysis. Results: T 2 and T 1 were significantly elevated in transplant recipients compared to controls (global T 2 : 50.5 ± 3.4 msec vs. 45.2 ± 2.3 msec, P < 0.01; global T 1 : 1037.8 ± 48.0 msec vs. 993.8 ± 34.1 msec, P < 0.01). Systolic longitudinal function was impaired in transplant recipients compared to controls (reduced peak systolic longitudinal velocities, 2.9 ± 1.1 cm/s vs. 5.1 ± 1.2 cm/s, P < 0.01; elevated systolic longitudinal dyssynchrony, 60.2 ± 30.2 msec vs. 32.1 ± 25.1 msec, P < 0.01). Correlation analysis revealed a significant positive relationship between T 2 and ECV (r = 0.45,P < 0.01). In addition, peak systolic longitudinal velocities demonstrated a significant inverse relationship with T 2 (global r = –0.29, P = 0.02), and systolic radial dyssynchrony was positively associated with peak T 2 and peak T 1 (r = 0.26,P = 0.04; r = 0.27,P = 0.03). Data Conclusion: MR techniques are sensitive to structural and functional differences in transplant recipients compared to controls. Structural (T 2 , T 1 ) and functional (peak myocardial velocities, dyssynchrony) measures were significantly associated, suggesting a structure–function relationship of cardiac abnormalities following heart transplant. Level of Evidence: 2. Technical Efficacy Stage: 2. J. Magn. Reson. Imaging 2019;49:678–687.

Original languageEnglish (US)
Pages (from-to)678-687
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume49
Issue number3
DOIs
StatePublished - Mar 2019

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Heart Transplantation
Tissue Expansion
Congenital Heart Defects
Echocardiography
Edema
Transplant Recipients
Prospective Studies
Transplants
Biopsy
Costs and Cost Analysis

Keywords

  • T -mapping
  • T -mapping
  • cardiac
  • heart transplantation
  • tissue phase mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{0e6788c56f804ad7931656cfbc78f6cb,
title = "Cardiac Structure–Function MRI in Patients After Heart Transplantation",
abstract = "Background: Following heart transplantation (Tx), recipients are closely monitored using endomyocardial biopsy, which is limited by cost and invasiveness, and echocardiography, which is limited regarding detailed structural and functional evaluation. Purpose: To test the feasibility of comprehensive structure–function cardiac MRI as a noninvasive modality to assess changes in myocardial structure and function. Study Type: Prospective. Subjects: MR was performed in 61 heart transplant recipients (age 47.9 ± 16.3 years, 39{\%} female) and 14 age-matched healthy controls (age 47.7 ± 16.7 years, 36{\%} female). Field Strength/Sequence: 1.5T; 2D CINE steady state free precession (SSF)P imaging, T 2 -mapping, pre- and postgadolinium contrast T 1 -mapping, and tissue-phase mapping (TPM). Assessment: Quantification of myocardial T 2 (as a measure of edema), pre- and post-Gd T 1 (allowing calculation of extracellular volume (ECV) to estimate interstitial expansion), and TPM-based assessment of peak regional left ventricular (LV) velocities, dyssynchrony, and twist. Statistical Tests: Comparisons between transplant recipients and controls were performed using independent samples t-tests. Relationships between structural (T 2 , T 1 , ECV) and functional measures (myocardial velocities, dyssynchrony, twist) were assessed using Pearson correlation analysis. Results: T 2 and T 1 were significantly elevated in transplant recipients compared to controls (global T 2 : 50.5 ± 3.4 msec vs. 45.2 ± 2.3 msec, P < 0.01; global T 1 : 1037.8 ± 48.0 msec vs. 993.8 ± 34.1 msec, P < 0.01). Systolic longitudinal function was impaired in transplant recipients compared to controls (reduced peak systolic longitudinal velocities, 2.9 ± 1.1 cm/s vs. 5.1 ± 1.2 cm/s, P < 0.01; elevated systolic longitudinal dyssynchrony, 60.2 ± 30.2 msec vs. 32.1 ± 25.1 msec, P < 0.01). Correlation analysis revealed a significant positive relationship between T 2 and ECV (r = 0.45,P < 0.01). In addition, peak systolic longitudinal velocities demonstrated a significant inverse relationship with T 2 (global r = –0.29, P = 0.02), and systolic radial dyssynchrony was positively associated with peak T 2 and peak T 1 (r = 0.26,P = 0.04; r = 0.27,P = 0.03). Data Conclusion: MR techniques are sensitive to structural and functional differences in transplant recipients compared to controls. Structural (T 2 , T 1 ) and functional (peak myocardial velocities, dyssynchrony) measures were significantly associated, suggesting a structure–function relationship of cardiac abnormalities following heart transplant. Level of Evidence: 2. Technical Efficacy Stage: 2. J. Magn. Reson. Imaging 2019;49:678–687.",
keywords = "T -mapping, T -mapping, cardiac, heart transplantation, tissue phase mapping",
author = "Dolan, {Ryan S.} and Rahsepar, {Amir A.} and Julie Blaisdell and Kai Lin and Kenichiro Suwa and Kambiz Ghafourian and Wilcox, {Jane E.} and Khan, {Sadiya S.} and Vorovich, {Esther E.} and Rich, {Jonathan D.} and Anderson, {Allen S.} and Yancy, {Clyde W.} and Collins, {Jeremy D.} and Michael Markl and Carr, {James C.}",
year = "2019",
month = "3",
doi = "10.1002/jmri.26275",
language = "English (US)",
volume = "49",
pages = "678--687",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

Cardiac Structure–Function MRI in Patients After Heart Transplantation. / Dolan, Ryan S.; Rahsepar, Amir A.; Blaisdell, Julie; Lin, Kai; Suwa, Kenichiro; Ghafourian, Kambiz; Wilcox, Jane E.; Khan, Sadiya S.; Vorovich, Esther E.; Rich, Jonathan D.; Anderson, Allen S.; Yancy, Clyde W.; Collins, Jeremy D.; Markl, Michael; Carr, James C.

In: Journal of Magnetic Resonance Imaging, Vol. 49, No. 3, 03.2019, p. 678-687.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiac Structure–Function MRI in Patients After Heart Transplantation

AU - Dolan, Ryan S.

AU - Rahsepar, Amir A.

AU - Blaisdell, Julie

AU - Lin, Kai

AU - Suwa, Kenichiro

AU - Ghafourian, Kambiz

AU - Wilcox, Jane E.

AU - Khan, Sadiya S.

AU - Vorovich, Esther E.

AU - Rich, Jonathan D.

AU - Anderson, Allen S.

AU - Yancy, Clyde W.

AU - Collins, Jeremy D.

AU - Markl, Michael

AU - Carr, James C.

PY - 2019/3

Y1 - 2019/3

N2 - Background: Following heart transplantation (Tx), recipients are closely monitored using endomyocardial biopsy, which is limited by cost and invasiveness, and echocardiography, which is limited regarding detailed structural and functional evaluation. Purpose: To test the feasibility of comprehensive structure–function cardiac MRI as a noninvasive modality to assess changes in myocardial structure and function. Study Type: Prospective. Subjects: MR was performed in 61 heart transplant recipients (age 47.9 ± 16.3 years, 39% female) and 14 age-matched healthy controls (age 47.7 ± 16.7 years, 36% female). Field Strength/Sequence: 1.5T; 2D CINE steady state free precession (SSF)P imaging, T 2 -mapping, pre- and postgadolinium contrast T 1 -mapping, and tissue-phase mapping (TPM). Assessment: Quantification of myocardial T 2 (as a measure of edema), pre- and post-Gd T 1 (allowing calculation of extracellular volume (ECV) to estimate interstitial expansion), and TPM-based assessment of peak regional left ventricular (LV) velocities, dyssynchrony, and twist. Statistical Tests: Comparisons between transplant recipients and controls were performed using independent samples t-tests. Relationships between structural (T 2 , T 1 , ECV) and functional measures (myocardial velocities, dyssynchrony, twist) were assessed using Pearson correlation analysis. Results: T 2 and T 1 were significantly elevated in transplant recipients compared to controls (global T 2 : 50.5 ± 3.4 msec vs. 45.2 ± 2.3 msec, P < 0.01; global T 1 : 1037.8 ± 48.0 msec vs. 993.8 ± 34.1 msec, P < 0.01). Systolic longitudinal function was impaired in transplant recipients compared to controls (reduced peak systolic longitudinal velocities, 2.9 ± 1.1 cm/s vs. 5.1 ± 1.2 cm/s, P < 0.01; elevated systolic longitudinal dyssynchrony, 60.2 ± 30.2 msec vs. 32.1 ± 25.1 msec, P < 0.01). Correlation analysis revealed a significant positive relationship between T 2 and ECV (r = 0.45,P < 0.01). In addition, peak systolic longitudinal velocities demonstrated a significant inverse relationship with T 2 (global r = –0.29, P = 0.02), and systolic radial dyssynchrony was positively associated with peak T 2 and peak T 1 (r = 0.26,P = 0.04; r = 0.27,P = 0.03). Data Conclusion: MR techniques are sensitive to structural and functional differences in transplant recipients compared to controls. Structural (T 2 , T 1 ) and functional (peak myocardial velocities, dyssynchrony) measures were significantly associated, suggesting a structure–function relationship of cardiac abnormalities following heart transplant. Level of Evidence: 2. Technical Efficacy Stage: 2. J. Magn. Reson. Imaging 2019;49:678–687.

AB - Background: Following heart transplantation (Tx), recipients are closely monitored using endomyocardial biopsy, which is limited by cost and invasiveness, and echocardiography, which is limited regarding detailed structural and functional evaluation. Purpose: To test the feasibility of comprehensive structure–function cardiac MRI as a noninvasive modality to assess changes in myocardial structure and function. Study Type: Prospective. Subjects: MR was performed in 61 heart transplant recipients (age 47.9 ± 16.3 years, 39% female) and 14 age-matched healthy controls (age 47.7 ± 16.7 years, 36% female). Field Strength/Sequence: 1.5T; 2D CINE steady state free precession (SSF)P imaging, T 2 -mapping, pre- and postgadolinium contrast T 1 -mapping, and tissue-phase mapping (TPM). Assessment: Quantification of myocardial T 2 (as a measure of edema), pre- and post-Gd T 1 (allowing calculation of extracellular volume (ECV) to estimate interstitial expansion), and TPM-based assessment of peak regional left ventricular (LV) velocities, dyssynchrony, and twist. Statistical Tests: Comparisons between transplant recipients and controls were performed using independent samples t-tests. Relationships between structural (T 2 , T 1 , ECV) and functional measures (myocardial velocities, dyssynchrony, twist) were assessed using Pearson correlation analysis. Results: T 2 and T 1 were significantly elevated in transplant recipients compared to controls (global T 2 : 50.5 ± 3.4 msec vs. 45.2 ± 2.3 msec, P < 0.01; global T 1 : 1037.8 ± 48.0 msec vs. 993.8 ± 34.1 msec, P < 0.01). Systolic longitudinal function was impaired in transplant recipients compared to controls (reduced peak systolic longitudinal velocities, 2.9 ± 1.1 cm/s vs. 5.1 ± 1.2 cm/s, P < 0.01; elevated systolic longitudinal dyssynchrony, 60.2 ± 30.2 msec vs. 32.1 ± 25.1 msec, P < 0.01). Correlation analysis revealed a significant positive relationship between T 2 and ECV (r = 0.45,P < 0.01). In addition, peak systolic longitudinal velocities demonstrated a significant inverse relationship with T 2 (global r = –0.29, P = 0.02), and systolic radial dyssynchrony was positively associated with peak T 2 and peak T 1 (r = 0.26,P = 0.04; r = 0.27,P = 0.03). Data Conclusion: MR techniques are sensitive to structural and functional differences in transplant recipients compared to controls. Structural (T 2 , T 1 ) and functional (peak myocardial velocities, dyssynchrony) measures were significantly associated, suggesting a structure–function relationship of cardiac abnormalities following heart transplant. Level of Evidence: 2. Technical Efficacy Stage: 2. J. Magn. Reson. Imaging 2019;49:678–687.

KW - T -mapping

KW - T -mapping

KW - cardiac

KW - heart transplantation

KW - tissue phase mapping

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