Cardiometabolic consequences of circadian disruption

Bingqian Zhu, Erin C. Hanlon, Kristen L. Knutson, Sirimon Reutrakul

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The circadian system involves a 24 hr pacemaker that organizes daily rhythms and synchronizes physiological functions. Circadian misalignment can occur between internal clocks and external influences (e.g., light-dark cycle, food intake) or internally between the central and peripheral clocks. Misalignment is common in shift workers and those with abnormal meal and/or sleep timing. Experimental and observational studies have linked circadian misalignment to adverse cardiometabolic health including elevated glucose levels, elevated blood pressure, dyslipidemia and cardiovascular disease. This article discusses recent findings, including emerging interventions to reduce cardiometabolic consequences of circadian misalignment such as light therapy, melatonin, sleep and meal timing interventions.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Sleep and Circadian Rhythms
Subtitle of host publicationVolume 1-6, Second Edition
PublisherElsevier
Pages644-656
Number of pages13
ISBN (Electronic)9780323910941
DOIs
StatePublished - Jan 1 2023

Keywords

  • Blood pressure
  • Cardiovascular
  • Chronotype
  • Circadian disruption
  • Diabetes
  • Glucose
  • Hypertension
  • Insulin
  • Light at night
  • Meal timing
  • Melatonin
  • Shift work
  • Sleep
  • Sleep variability

ASJC Scopus subject areas

  • General Neuroscience

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