TY - JOUR
T1 - Cardiomyocyte injury assessed by a highly sensitive troponin assay and sudden cardiac death in the community
T2 - The cardiovascular health study
AU - Hussein, Ayman A.
AU - Gottdiener, John S.
AU - Bartz, Traci M.
AU - Sotoodehnia, Nona
AU - Defilippi, Christopher
AU - Dickfeld, Timm
AU - Deo, Rajat
AU - Siscovick, David
AU - Stein, Phyllis K.
AU - Lloyd-Jones, Donald
N1 - Funding Information:
This research was supported by the National Heart, Lung, and Blood Institute (NHLBI) contracts HHSN268201200036C, N01-HC-85239, N01-HC-85079 through N01-HC-85086 , N01-HC-35129 , N01-HC-15103 , N01-HC-55222 , N01-HC-75150 , N01-HC-45133 , and NHLBI grant HL080295 , with additional contributions from the National Institute of Neurological Disorders and Stroke. Additional support was provided through AG-023629, AG-15928, AG-20098, and AG-027058 from the National Institute on Aging . See also http://www.chs-nhlbi.org . Dr. deFilippi has received honoraria, consulting fees, and grant support from Roche Diagnostics and Siemens Healthcare Diagnostics ; and consulting fees and grant support from Critical Diagnostics and BG Medicine . Dr. Dickfeld has received consulting fees and grant support from Biosense Webster ; and grant support from General Electric . All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
PY - 2013/12/3
Y1 - 2013/12/3
N2 - Objectives This study sought to determine the association between markers of cardiomyocyte injury in ambulatory subjects and sudden cardiac death (SCD). Background The pathophysiology of SCD is complex but is believed to be associated with an abnormal cardiac substrate in most cases. The association between biomarkers of cardiomyocyte injury in ambulatory subjects and SCD has not been investigated. Methods Levels of cardiac troponin T, a biomarker of cardiomyocyte injury, were measured by a highly sensitive assay (hsTnT) in 4,431 ambulatory participants in the Cardiovascular Health Study, a longitudinal community-based prospective cohort study. Serial measures were obtained in 3,089 subjects. All deaths, including SCD, were adjudicated by a central events committee. Results Over a median follow-up of 13.1 years, 246 participants had SCD. Baseline levels of hsTnT were significantly associated with SCD (hazard ratio [HR] for +1 log(hsTnT): 2.04, 95% confidence interval [CI]: 1.78 to 2.34]. This association persisted in covariate-adjusted Cox analyses accounting for baseline risk factors (HR: 1.30, 95% CI: 1.05 to 1.62), as well as for incident heart failure and myocardial infarction (HR: 1.26, 95% CI: 1.01 to 1.57). The population was also categorized into 3 groups based on baseline hsTnT levels and SCD risk [fully adjusted HR: 1.89 vs. 1.55 vs. 1 (reference group) for hsTnT ≥12.10 vs. 5.01 to 12.09 vs. ≤5.00 pg/ml, respectively; ptrend = 0.005]. On serial measurements, change in hsTnT levels was also associated with SCD risk (fully adjusted HR for +1 pg/ml per year increase from baseline: 1.03, 95% CI: 1.01 to 1.06). Conclusions The findings suggest an association between cardiomyocyte injury in ambulatory subjects and SCD risk beyond that of traditional risk factors.
AB - Objectives This study sought to determine the association between markers of cardiomyocyte injury in ambulatory subjects and sudden cardiac death (SCD). Background The pathophysiology of SCD is complex but is believed to be associated with an abnormal cardiac substrate in most cases. The association between biomarkers of cardiomyocyte injury in ambulatory subjects and SCD has not been investigated. Methods Levels of cardiac troponin T, a biomarker of cardiomyocyte injury, were measured by a highly sensitive assay (hsTnT) in 4,431 ambulatory participants in the Cardiovascular Health Study, a longitudinal community-based prospective cohort study. Serial measures were obtained in 3,089 subjects. All deaths, including SCD, were adjudicated by a central events committee. Results Over a median follow-up of 13.1 years, 246 participants had SCD. Baseline levels of hsTnT were significantly associated with SCD (hazard ratio [HR] for +1 log(hsTnT): 2.04, 95% confidence interval [CI]: 1.78 to 2.34]. This association persisted in covariate-adjusted Cox analyses accounting for baseline risk factors (HR: 1.30, 95% CI: 1.05 to 1.62), as well as for incident heart failure and myocardial infarction (HR: 1.26, 95% CI: 1.01 to 1.57). The population was also categorized into 3 groups based on baseline hsTnT levels and SCD risk [fully adjusted HR: 1.89 vs. 1.55 vs. 1 (reference group) for hsTnT ≥12.10 vs. 5.01 to 12.09 vs. ≤5.00 pg/ml, respectively; ptrend = 0.005]. On serial measurements, change in hsTnT levels was also associated with SCD risk (fully adjusted HR for +1 pg/ml per year increase from baseline: 1.03, 95% CI: 1.01 to 1.06). Conclusions The findings suggest an association between cardiomyocyte injury in ambulatory subjects and SCD risk beyond that of traditional risk factors.
KW - general population
KW - myocytes
KW - sudden death
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U2 - 10.1016/j.jacc.2013.07.049
DO - 10.1016/j.jacc.2013.07.049
M3 - Article
C2 - 23973690
AN - SCOPUS:84888382638
VL - 62
SP - 2112
EP - 2120
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 22
ER -