Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review

Jonathan D. Newman*, Deepak L. Bhatt, Sanjay Rajagopalan, John R. Balmes, Michael Brauer, Patrick N. Breysse, Alison G.M. Brown, Mercedes R. Carnethon, Wayne E. Cascio, Gwen W. Collman, Lawrence J. Fine, Nadia N. Hansel, Adrian Hernandez, Judith S. Hochman, Michael Jerrett, Bonnie R. Joubert, Joel D. Kaufman, Ali O. Malik, George A. Mensah, David E. NewbyJennifer L. Peel, Jeffrey Siegel, David Siscovick, Betsy L. Thompson, Junfeng Zhang, Robert D. Brook

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Fine particulate air pollution <2.5 μm in diameter (PM2.5) is a major environmental threat to global public health. Multiple national and international medical and governmental organizations have recognized PM2.5 as a risk factor for cardiopulmonary diseases. A growing body of evidence indicates that several personal-level approaches that reduce exposures to PM2.5 can lead to improvements in health endpoints. Novel and forward-thinking strategies including randomized clinical trials are important to validate key aspects (e.g., feasibility, efficacy, health benefits, risks, burden, costs) of the various protective interventions, in particular among real-world susceptible and vulnerable populations. This paper summarizes the discussions and conclusions from an expert workshop, Reducing the Cardiopulmonary Impact of Particulate Matter Air Pollution in High Risk Populations, held on May 29 to 30, 2019, and convened by the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Centers for Disease Control and Prevention.

Original languageEnglish (US)
Pages (from-to)2878-2894
Number of pages17
JournalJournal of the American College of Cardiology
Issue number24
StatePublished - Dec 15 2020


  • cardiopulmonary disease
  • cardiovascular disease
  • fine particulate air pollution
  • portable air cleaner
  • randomized clinical trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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