TY - JOUR
T1 - Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children
T2 - An analysis of the National Inpatient Sample
AU - Silverberg, Jonathan I
AU - Kwa, Lauren
AU - Kwa, Michael C.
AU - Laumann, Anne E
AU - Ardalan, Kaveh
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.
AB - Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.
KW - Atherosclerosis
KW - Cardiovascular risk factors
KW - Cerebral infarction
KW - Cerebrovascular disease
KW - Comorbidities
KW - Dermatomyositis
KW - Diabetes
KW - Hypertension
KW - Obesity
KW - Racial differences
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U2 - 10.1093/rheumatology/kex465
DO - 10.1093/rheumatology/kex465
M3 - Article
C2 - 29373707
SN - 1462-0324
VL - 57
SP - 694
EP - 702
JO - Rheumatology (United Kingdom)
JF - Rheumatology (United Kingdom)
IS - 4
ER -