Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children

An analysis of the National Inpatient Sample

Jonathan I Silverberg*, Lauren Kwa, Michael C. Kwa, Anne E Laumann, Kaveh Ardalan

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.

Original languageEnglish (US)
Pages (from-to)694-702
Number of pages9
JournalRheumatology (United Kingdom)
Volume57
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Comorbidity
Inpatients
Hospitalization
Lipodystrophy
Cerebrovascular Disorders
Brachial Artery
Transient Ischemic Attack
Cerebral Infarction
Bradycardia
Hypotension
Cardiac Arrhythmias
Atherosclerosis
Cardiovascular Diseases
Obesity
Heart Rate
Logistic Models
Odds Ratio
Pediatrics
Hypertension
Lipids

Keywords

  • Atherosclerosis
  • Cardiovascular risk factors
  • Cerebral infarction
  • Cerebrovascular disease
  • Comorbidities
  • Dermatomyositis
  • Diabetes
  • Hypertension
  • Obesity
  • Racial differences

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Cite this

@article{26b5a44528204a0194e029d342123214,
title = "Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: An analysis of the National Inpatient Sample",
abstract = "Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20{\%} of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95{\%} CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.",
keywords = "Atherosclerosis, Cardiovascular risk factors, Cerebral infarction, Cerebrovascular disease, Comorbidities, Dermatomyositis, Diabetes, Hypertension, Obesity, Racial differences",
author = "Silverberg, {Jonathan I} and Lauren Kwa and Kwa, {Michael C.} and Laumann, {Anne E} and Kaveh Ardalan",
year = "2018",
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doi = "10.1093/rheumatology/kex465",
language = "English (US)",
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Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children : An analysis of the National Inpatient Sample. / Silverberg, Jonathan I; Kwa, Lauren; Kwa, Michael C.; Laumann, Anne E; Ardalan, Kaveh.

In: Rheumatology (United Kingdom), Vol. 57, No. 4, 01.04.2018, p. 694-702.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children

T2 - An analysis of the National Inpatient Sample

AU - Silverberg, Jonathan I

AU - Kwa, Lauren

AU - Kwa, Michael C.

AU - Laumann, Anne E

AU - Ardalan, Kaveh

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.

AB - Objective. JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children. Methods. Data from the 2002-12 National Inpatient Sample was analysed, including ~20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations). Results. JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)]. Conclusions. There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.

KW - Atherosclerosis

KW - Cardiovascular risk factors

KW - Cerebral infarction

KW - Cerebrovascular disease

KW - Comorbidities

KW - Dermatomyositis

KW - Diabetes

KW - Hypertension

KW - Obesity

KW - Racial differences

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U2 - 10.1093/rheumatology/kex465

DO - 10.1093/rheumatology/kex465

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JO - Rheumatology

JF - Rheumatology

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