Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States

Lauren Kwa, Michael C. Kwa, Jonathan I. Silverberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background Psoriasis has been shown to be associated with cardiovascular disease in adults. Little is known about cardiovascular risk in pediatric psoriasis. Objective To determine if there is an association between pediatric psoriasis and cardiovascular comorbidities. Methods Data were analyzed from the 2002-2012 Nationwide Inpatient Sample, which included 4,884,448 hospitalized children aged 0-17 years. Bivariate and multivariate survey logistic regression models were created to calculate the odds of psoriasis on cardiovascular comorbidities. Results In multivariate survey logistic regression models adjusting for age, sex, and race/ethnicity, pediatric psoriasis was significantly associated with 5 of 10 cardiovascular comorbidities (adjusted odds ratio [95% confidence interval]), including obesity (3.15 [2.46-4.05]), hypertension (2.63 [1.93-3.59]), diabetes (2.90 [1.90-4.42]), arrhythmia (1.39 [1.02-1.88]), and valvular heart disease (1.90 [1.07-3.37]). The highest odds of cardiovascular risk factors occurred in blacks and Hispanics and children ages 0-9 years, but there were no sex differences. Limitations The study was limited to hospitalized children. We were unable to assess the impact of psoriasis treatment or family history on cardiovascular risk. Conclusion Pediatric psoriasis is associated with higher odds of multiple cardiovascular comorbidities among hospitalized patients. Strategies for mitigating excess cardiovascular risk in pediatric psoriasis need to be determined.

Original languageEnglish (US)
Pages (from-to)1023-1029
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume77
Issue number6
DOIs
StatePublished - Dec 2017

Keywords

  • arrhythmia
  • cardiovascular risk factors
  • comorbidities
  • diabetes
  • hyperlipidemia
  • hypertension
  • obesity
  • psoriasis
  • racial differences

ASJC Scopus subject areas

  • Dermatology

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