Cardiovascular Complications of HIV in Endemic Countries

Matthew J. Feinstein*, Milana Bogorodskaya, Gerald S. Bloomfield, Rajesh Vedanthan, Mark J. Siedner, Gene F. Kwan, Christopher T. Longenecker

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Effective combination antiretroviral therapy (ART) has enabled human immunodeficiency virus (HIV) infection to evolve from a generally fatal condition to a manageable chronic disease. This transition began two decades ago in high-income countries and has more recently begun in lower income, HIV endemic countries (HIV-ECs). With this transition, there has been a concurrent shift in clinical and public health burden from AIDS-related complications and opportunistic infections to those associated with well-controlled HIV disease, including cardiovascular disease (CVD). In the current treatment era, traditional CVD risk factors and HIV-related factors both contribute to an elevated risk of myocardial infarction, stroke, heart failure, and arrhythmias. In HIV-ECs, the high prevalence of persons living with HIV and growing prevalence of CVD risk factors will contribute to a growing epidemic of HIV-associated CVD. In this review, we discuss the epidemiology and pathophysiology of cardiovascular complications of HIV and the resultant implications for public health efforts in HIV-ECs.

Original languageEnglish (US)
Article number113
JournalCurrent Cardiology Reports
Issue number11
StatePublished - Nov 1 2016


  • Cardiovascular epidemiology
  • Global health
  • HIV
  • Health disparities
  • Human immunodeficiency virus
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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