Cardiovascular effects of conventional positive pressure ventilation and airway pressure release ventilation

J. Rasanen, J. B. Downs, M. C. Stock

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


The hemodynamic sequelae of conventional positive pressure ventilation (CPPV), airway pressure release ventilation (APRV), and spontaneous breathing were compared with continuous positive airway pressure (CPAP) in ten anesthetized dogs who had ventilatory failure with and without parenchymal lung injury. The APRV corrected respiratory acidosis without significantly effecting arterial blood oxygenation, venous admixture, cardiovascular function, or tissue oxygen utilization. Application of CPPV precipitated marked depressions in blood pressure, stroke volume, and cardiac output. A concomitant decrease in venous admixture did not compensate for these adverse cardiovascular effects. Deterioration of tissue oxygen delivery resulted in oxygen supply-demand imbalance during CPPV. The results of this experimental study indicate that if ventilatory augmentation of subjects who require CPAP is desired, APRV will enhance alveolar ventilation without compromising circulating function and tissue oxygen balance, whereas CPPV will impair cardiovascular function significantly.

Original languageEnglish (US)
Pages (from-to)911-915
Number of pages5
Issue number5
StatePublished - 1988

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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